Challenging conventional wisdom : The etiologic role of dopamine oxidative stress in Parkinson's disease
Identifieur interne : 003E77 ( Main/Exploration ); précédent : 003E76; suivant : 003E78Challenging conventional wisdom : The etiologic role of dopamine oxidative stress in Parkinson's disease
Auteurs : J. Eric Ahlskog [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2004.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Oxidative stress is well documented in Parkinson's disease (PD) and has been attributed to dopamine oxidative metabolism. However, evidence of oxidative stress is found in a variety of neurodegenerative disorders, suggesting that more general factors are responsible or that cytodestructive processes secondarily generate oxyradical products. Increasing evidence points away from dopamine metabolism as an important contributor to PD neurodegeneration. Predictions from the dopamine oxidative stress hypothesis of PD reveal multiple inconsistencies. Although the clinical and therapeutic importance of the nigrostriatal dopaminergic system is undeniable, PD neuropathology is much more widespread.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 001F15
- to stream PascalFrancis, to step Curation: 000E06
- to stream PascalFrancis, to step Checkpoint: 002215
- to stream Main, to step Merge: 005A53
- to stream Main, to step Curation: 003E77
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Challenging conventional wisdom : The etiologic role of dopamine oxidative stress in Parkinson's disease</title><author><name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J. Eric" last="Ahlskog">J. Eric Ahlskog</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Mayo Clinic</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">05-0225487</idno><date when="2004">2004</date><idno type="stanalyst">PASCAL 05-0225487 INIST</idno><idno type="RBID">Pascal:05-0225487</idno><idno type="wicri:Area/PascalFrancis/Corpus">001F15</idno><idno type="wicri:Area/PascalFrancis/Curation">000E06</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002215</idno><idno type="wicri:doubleKey">0885-3185:2004:Ahlskog J:challenging:conventional:wisdom</idno><idno type="wicri:Area/Main/Merge">005A53</idno><idno type="wicri:Area/Main/Curation">003E77</idno><idno type="wicri:Area/Main/Exploration">003E77</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Challenging conventional wisdom : The etiologic role of dopamine oxidative stress in Parkinson's disease</title><author><name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J. Eric" last="Ahlskog">J. Eric Ahlskog</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Mayo Clinic</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dopamine</term><term>Levodopa</term><term>Nervous system diseases</term><term>Oxidative stress</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Dopamine</term><term>Stress oxydatif</term><term>Parkinson maladie</term><term>Lévodopa</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Oxidative stress is well documented in Parkinson's disease (PD) and has been attributed to dopamine oxidative metabolism. However, evidence of oxidative stress is found in a variety of neurodegenerative disorders, suggesting that more general factors are responsible or that cytodestructive processes secondarily generate oxyradical products. Increasing evidence points away from dopamine metabolism as an important contributor to PD neurodegeneration. Predictions from the dopamine oxidative stress hypothesis of PD reveal multiple inconsistencies. Although the clinical and therapeutic importance of the nigrostriatal dopaminergic system is undeniable, PD neuropathology is much more widespread.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Minnesota</li></region></list><tree><country name="États-Unis"><region name="Minnesota"><name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J. Eric" last="Ahlskog">J. Eric Ahlskog</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003E77 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003E77 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:05-0225487
|texte= Challenging conventional wisdom : The etiologic role of dopamine oxidative stress in Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |